IACS-8803 diammonium is a potent cyclic dinucleotide STING agonist with potent systemic anti-tumor effects.

Physicochemical Properties

Molecular Formula	C20H29FN12O9P2S2
Molecular Weight	726.60
Related CAS #	IACS-8803 disodium;2243079-36-7;IACS-8803;2095690-70-1
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	In mice with bilateral B16-OVA melanomas, IACS-8803 diammonium (10 µg; intratumoral injection) has the best anticancer activity[1].
References	[1]. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.

Solubility Data

Solubility (In Vitro)	H2O :~15 mg/mL (~20.64 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 15 mg/mL (20.64 mM) in DMSO MaximumSolubilityTest (add these co-solvents sequentially from left to right, and one by one), clear solution; with heating and sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3763 mL	6.8814 mL	13.7627 mL
	5 mM	0.2753 mL	1.3763 mL	2.7525 mL
	10 mM	0.1376 mL	0.6881 mL	1.3763 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.