Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a co-solvent for the preparation of low-solubility active molecules SDD. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is effective orally, has no acute/subchronic/chronic toxicity to rats, LD50 >2.5 g/kg.

Physicochemical Properties

Molecular Formula	C10H22O9
Molecular Weight	286.2763
Exact Mass	286.126
CAS #	71138-97-1
PubChem CID	121950
Appearance	White to off-white solid powder
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Heavy Atom Count	19
Complexity	147
Defined Atom Stereocenter Count	0
SMILES	CC(CO)O.CC(=O)O.CO.C(CC(=O)O)C(=O)O
InChi Key	ZUAAPNNKRHMPKG-UHFFFAOYSA-N
InChi Code	InChI=1S/C4H6O4.C3H8O2.C2H4O2.CH4O/c5-3(6)1-2-4(7)8;1-3(5)2-4;1-2(3)4;1-2/h1-2H2,(H,5,6)(H,7,8);3-5H,2H2,1H3;1H3,(H,3,4);2H,1H3
Chemical Name	acetic acid;butanedioic acid;methanol;propane-1,2-diol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	Rats treated with 2.5 g/kg po; single dose of hydroxypropylmethyl cellulose acetate succinate do not exhibit any appreciable acute toxicity [1]. Rats treated once a day for two months, six days a week, with 0.63, 1.25, and 2.5 g/kg of hydroxypropylmethyl cellulose acetate succinate po showed no appreciable subchronic toxicity [1]. Rats administered 1.25 g/kg or 2.5 g/kg of hydroxypropylmethyl cellulose acetate succinate orally once daily for two months, six days a week, did not exhibit substantial chronic toxicity [1].
References	[1]. Toxicological studies of hydroxypropylmethylcellulose acetate succinate--acute toxicity in rats and rabbits, and subchronic and chronic toxicities in rats. J Toxicol Sci. 1985 Oct;10 Suppl 2:147-85.
Additional Infomation	See also: Hypromellose Acetate Succinate 06081224 (3 Mm2/S) (annotation moved to); Hypromellose acetate succinate 12070923 (3 MM2/S) (annotation moved to); Hypromellose Acetate Succinate 16070722 (3 Mm2/S) (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL H2O: < 0.1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.4931 mL	17.4654 mL	34.9308 mL
	5 mM	0.6986 mL	3.4931 mL	6.9862 mL
	10 mM	0.3493 mL	1.7465 mL	3.4931 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.