Physicochemical Properties
| Molecular Formula | C6H7K3O8 |
| Molecular Weight | 324.4099 |
| Exact Mass | 323.905 |
| CAS # | 6100-05-6 |
| Related CAS # | Lithium citrate tetrahydrate;6080-58-6;Sodium citrate dihydrate;6132-04-3;Citric acid;77-92-9;Hydroxycitric acid;6205-14-7 |
| PubChem CID | 2735208 |
| Appearance | White to off-white solid powder |
| Density | 1.98 |
| Boiling Point | 309.6ºC at 760 mmHg |
| Melting Point | 275 °C (dec.)(lit.) |
| Flash Point | 155.2ºC |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 2 |
| Heavy Atom Count | 17 |
| Complexity | 211 |
| Defined Atom Stereocenter Count | 0 |
| InChi Key | PJAHUDTUZRZBKM-UHFFFAOYSA-K |
| InChi Code | InChI=1S/C6H8O7.3K.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;1H2/q;3*+1;/p-3 |
| Chemical Name | tripotassium;2-hydroxypropane-1,2,3-tricarboxylate;hydrate |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro | Citrate exhibited inhibitory effects on HIF in ARPE19 cells and 661W cells when compared to pyramids. comparable to citric acid, which in 661W and ARPE19 cells can inhibit downstream genes including Hif1a. Citric acid has the ability to suppress HIF in ARPE19 and 661W cells. HIF-1α protein expression is increased by inhibiting CoCl2 [2]. Citric acid speeds up energy activation and decreases lipid droplet accumulation in chicken liver cells. Otherwise, citric acid boosts mitochondrial performance and antioxidant status to shield cells against apoptotic ER stress [2]. |
| ln Vivo | Treatment with 100–200 mg/kg of citric acid decreased serum muscle nutrition and blood urea nitrogen, two indicators of renal failure. First, citric acid inhibits inflammatory cytokines including MCP-1, IL-1β, and IL-6 that are generated by calcium oxalate. This is demonstrated by the crystal deposits of calcium oxalate in electrodes treated with citric acid (C57BL/6J electrode). It can lessen the harm that calcium oxalate crystals bring to renal tubules and cell necrosis [1]. |
| References |
[1]. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3. [2]. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049. [3]. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667. [4]. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600. |
| Additional Infomation |
Potassium citrate monohydrate is a hydrate that is the monohydrate form of potassium citrate. It has a role as a diuretic. It contains a potassium citrate (anhydrous). A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher. See also: Potassium Citrate (annotation moved to). |
Solubility Data
| Solubility (In Vitro) |
H2O : ~120 mg/mL (~369.90 mM) DMSO :< 1 mg/mL |
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (308.25 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0825 mL | 15.4126 mL | 30.8252 mL | |
| 5 mM | 0.6165 mL | 3.0825 mL | 6.1650 mL | |
| 10 mM | 0.3083 mL | 1.5413 mL | 3.0825 mL |