Human PD-L1 inhibitor V TFA is a human PD-1 protein binding peptide with a Kd of 3.32 μM, which can inhibit the binding of human PD-1/PD-L1.

Physicochemical Properties

Molecular Formula	C65H104N20O18S.XC2HF3O2
Molecular Weight	1485.71 (free base)
Related CAS #	Human PD-L1 inhibitor V;2815311-61-4
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	The peptide known as human PD-L1 inhibitor V(Ar5M_2) has the anchor residues Y56, R113, A121, D122, and Y123 in its design[1].
References	[1]. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976.

Solubility Data

Solubility (In Vitro)	H2O :~100 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)