Hsp90-IN-37 (Z-2) is a heat shock protein 90 (Hsp90) inhibitor with an inhibition rate of 69% on Hsp90 enzyme activity. Hsp90-IN-37 has anti-tumor activity.

Physicochemical Properties

Molecular Formula	C12H15N3O2
Molecular Weight	233.27
CAS #	1383133-23-0
Appearance	Solid powder
SMILES	O(C(N1C(N)=NC2C=CC=CC1=2)=O)C(C)(C)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation. Anticancer Agents Med Chem. 2021;21(18):2583-2591.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.2869 mL	21.4344 mL	42.8688 mL
	5 mM	0.8574 mL	4.2869 mL	8.5738 mL
	10 mM	0.4287 mL	2.1434 mL	4.2869 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.