Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone) is a sesquiterpene extracted from Impatiens parviflora and is the major component of volatile oil. Hexahydrofarnesyl acetone has antibacterial and anti-inflammatory activity and may be used in pain relief studies.

Physicochemical Properties

Molecular Formula	C18H36O
Molecular Weight	268.48
Exact Mass	268.276
CAS #	502-69-2
PubChem CID	10408
Appearance	Colorless to light yellow liquid
Density	0.8±0.1 g/cm3
Boiling Point	316.8±10.0 °C at 760 mmHg
Flash Point	95.1±12.6 °C
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.440
LogP	7.26
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	12
Heavy Atom Count	19
Complexity	220
Defined Atom Stereocenter Count	0
SMILES	CC(C)CCCC(C)CCCC(C)CCCC(=O)C
InChi Key	WHWDWIHXSPCOKZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C18H36O/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19/h15-17H,6-14H2,1-5H3
Chemical Name	6,10,14-trimethylpentadecan-2-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Albizia lebbeck and Albizia zygia volatile oils exhibit anti-nociceptive and anti-inflammatory properties in pain models.J Ethnopharmacol. 2021 Mar 25;268:113676. [2]. Essential oil composition and antibacterial activity of Lindera nacusua (D. Don) Merr. Nat Prod Res. 2016 Dec;30(23):2704-2706.
Additional Infomation	Hexahydrofarnesyl acetone is a ketone. 6,10,14-Trimethylpentadecan-2-one has been reported in Leea guineensis, Pinellia ternata, and other organisms with data available.

Solubility Data

Solubility (In Vitro)

DMSO : 33.33 mg/mL (124.14 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (9.31 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.31 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (9.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.7247 mL	18.6234 mL	37.2467 mL
	5 mM	0.7449 mL	3.7247 mL	7.4493 mL
	10 mM	0.3725 mL	1.8623 mL	3.7247 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.