Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA). Heptadecanoic acid has been linked to a number of conditions such as coronary heart disease, prediabetes and type 2 diabetes, and multiple sclerosis.

Physicochemical Properties

Molecular Formula	C17H34O2
Molecular Weight	270.45
Exact Mass	270.255
CAS #	506-12-7
Related CAS #	Heptadecanoic acid-d3;202528-95-8;Heptadecanoic acid-d33;352431-41-5
PubChem CID	10465
Appearance	White to off-white <59°C powder,>61°C liquid
Density	0.9±0.1 g/cm3
Boiling Point	298.5±0.0 °C at 760 mmHg
Melting Point	59-61 °C(lit.)
Flash Point	158.4±12.5 °C
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.455
LogP	7.68
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	15
Heavy Atom Count	19
Complexity	190
Defined Atom Stereocenter Count	0
SMILES	CCCCCCCCCCCCCCCCC(=O)O
InChi Key	KEMQGTRYUADPNZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)
Chemical Name	heptadecanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Heptadecanoic acid inhibits cell proliferation in PC‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistancey. Oncol Rep. 2019 Jun;41(6):3499-3507.

Additional Infomation

Heptadecanoic acid is a C17 saturated fatty acid and trace component of fats in ruminants. It has a role as a mammalian metabolite, a Daphnia magna metabolite and an algal metabolite. It is a long-chain fatty acid and a straight-chain saturated fatty acid. It is a conjugate acid of a margarate. Margaric acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Heptadecanoic acid has been reported in Hoya crassipes, Hoya pseudolanceolata, and other organisms with data available. Margaric Acid is a saturated long-chain fatty acid with a 17-carbon backbone. Margaric acid is found naturally as a minor component of the fat and milk fat of ruminants. Heptadecanoic acid is a metabolite found in or produced by Saccharomyces cerevisiae. See also: Fatty acids, C14-22 (annotation moved to); Fatty acids, C16-18 (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (369.75 mM) H2O: < 0.1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: 3 mg/mL (11.09 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (9.24 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.6975 mL	18.4877 mL	36.9754 mL
	5 mM	0.7395 mL	3.6975 mL	7.3951 mL
	10 mM	0.3698 mL	1.8488 mL	3.6975 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.