HU 331 (HU 331) is a highly specific topoisomerase II inhibitor with anticancer activity. HU 331 has shown good inhibitory effects on human cancer cell lines in vitro and human tumor xenografts in nude mice in vivo.

Physicochemical Properties

Molecular Formula	C21H28O3
Molecular Weight	328.45
CAS #	137252-25-6
SMILES	CCCCCC1=CC(=O)C(=C(C1=O)O)[C@@H]2C=C(C)CC[C@H]2C(=C)C
Synonyms	VCE 004
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Topoisomerase II
References	[1]. HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitorJ. Molecular Cancer Therapeutics, 2007, 6(1): 173-183.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.0446 mL	15.2230 mL	30.4460 mL
	5 mM	0.6089 mL	3.0446 mL	6.0892 mL
	10 mM	0.3045 mL	1.5223 mL	3.0446 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.