HIV-IN-6 is a novel HIV-Ⅰ viral replication inhibitor acting by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck.

Physicochemical Properties

Molecular Formula	C20H16N4O3S
Molecular Weight	392.43
Exact Mass	392.094
CAS #	301357-74-4
PubChem CID	2309588
Appearance	Light yellow to yellow solid powder
LogP	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	28
Complexity	605
Defined Atom Stereocenter Count	0
SMILES	C1C=CC=CC=1S(=O)(NC1C(NC2C=CC=C(O)C=2)=NC2=C(C=CC=C2)N=1)=O
InChi Key	BNHZFBKIEIPSHA-UHFFFAOYSA-N
InChi Code	InChI=1S/C20H16N4O3S/c25-15-8-6-7-14(13-15)21-19-20(23-18-12-5-4-11-17(18)22-19)24-28(26,27)16-9-2-1-3-10-16/h1-13,25H,(H,21,22)(H,23,24)
Chemical Name	N-[3-(3-hydroxyanilino)quinoxalin-2-yl]benzenesulfonamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

Targeting an hiv-1 nef-host cell kinase complex.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~254.82 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1 mg/mL (2.55 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 + to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5482 mL	12.7411 mL	25.4823 mL
	5 mM	0.5096 mL	2.5482 mL	5.0965 mL
	10 mM	0.2548 mL	1.2741 mL	2.5482 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.