HIV-1 inhibitor-80 (compound M44) is a HIV-1 inhibitor with EC50 of 5-148 nM. HIV-1 inhibitor-80 has good metabolic stability and cytotoxicity in human plasma and human liver microsomes.

Physicochemical Properties

Molecular Formula	C26H19N7O
Molecular Weight	445.48
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	HIV-1
References	[1]. Structure-based discovery of novel diarylpyrimidines as potent and selective Non-Nucleoside reverse transcriptase inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to CNNH2-Biphenyl-Diarylpyrimidines. Eur J Med Chem. 2025 Jan 12:285:117271.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2448 mL	11.2238 mL	22.4477 mL
	5 mM	0.4490 mL	2.2448 mL	4.4895 mL
	10 mM	0.2245 mL	1.1224 mL	2.2448 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.