HIV-1 inhibitor-77 (compound 13) is a HIV-1 inhibitor. HIV-1 inhibitor-77 can neutralize HIV-1CH58TF, HIV-1 JRFL and HIV-1 AD8 viruses with IC50 values of 0.14 μM, 8.28 μM and 2.92 μM, respectively.

Physicochemical Properties

Molecular Formula	C25H32CLF4N7O5
Molecular Weight	622.01
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Optimization of a Piperidine CD4-Mimetic Scaffold Sensitizing HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity. ACS Med Chem Lett. 2024;15(11):1961-1969. Published 2024 Oct 28.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6077 mL	8.0385 mL	16.0769 mL
	5 mM	0.3215 mL	1.6077 mL	3.2154 mL
	10 mM	0.1608 mL	0.8038 mL	1.6077 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.