HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (antagonist) with IC50 of 16 nM. For more details, check and find compound 232 from the patent WO2015035223A1.

Physicochemical Properties

Molecular Formula	C17H13F2NO4S
Molecular Weight	365.3512
Exact Mass	365.053
CAS #	1672666-82-8
PubChem CID	117947105
Appearance	White to off-white solid powder
Density	1.52±0.1 g/cm3(Predicted)
Boiling Point	530.6±50.0 °C(Predicted)
LogP	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Heavy Atom Count	25
Complexity	643
Defined Atom Stereocenter Count	0
InChi Key	GTHLUQQEKIJSME-UHFFFAOYSA-N
InChi Code	InChI=1S/C17H13F2NO4S/c1-25(22,23)15-3-2-14(12-7-13(19)17(21)16(12)15)24-11-5-9(8-20)4-10(18)6-11/h2-6,13,17,21H,7H2,1H3
Chemical Name	3-fluoro-5-[(2-fluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl)oxy]benzonitrile
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Aryl ethers and uses thereof. WO2015035223A1.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~273.71 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (6.84 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.7371 mL	13.6855 mL	27.3710 mL
	5 mM	0.5474 mL	2.7371 mL	5.4742 mL
	10 mM	0.2737 mL	1.3686 mL	2.7371 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.