HER2-IN-16 (Compound 14) is a HER2 inhibitor that inhibits YVMA HER2 exon 20 insertion mutation (HER2 YVMA) with IC50 <200 nM. HER2-IN-16 inhibits the proliferation of HER2 YVMA mutant BaF3 cells with IC50 <200 nM and improves non-small cell lung cancer (NSCLC).

Physicochemical Properties

Molecular Formula	C25H23N9O2
Molecular Weight	481.51
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Her2 exon 20 YVMA insertion <200 nM (IC50)
References	[1]. Compounds and methods for modulating her2. Patent WO2024044570.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0768 mL	10.3840 mL	20.7680 mL
	5 mM	0.4154 mL	2.0768 mL	4.1536 mL
	10 mM	0.2077 mL	1.0384 mL	2.0768 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.