HDAC8-IN-7 (H7E) is an inhibitor of HDAC8, which exerts retinal protection against glaucomatous damage by ameliorating abnormal Müller glial activity and oxidative stress. HDAC8-IN-7 alleviates the functional and structural defects of the inner retina.

Physicochemical Properties

Molecular Formula	C18H20N2O5
Molecular Weight	344.36
Appearance	Typically exists as solid at room temperature
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress. Biomed Pharmacother. 2024 Apr 4:174:116538.

Solubility Data

Solubility (In Vitro)	May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
Solubility (In Vivo)	H7E (30mg/kg) dissolved in a cosolvent (EtOH: cremophor: normal saline = 1: 1: 8)[1]. (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9039 mL	14.5197 mL	29.0394 mL
	5 mM	0.5808 mL	2.9039 mL	5.8079 mL
	10 mM	0.2904 mL	1.4520 mL	2.9039 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.