PeptideDB

HDAC6-IN-34 1432508-73-0

HDAC6-IN-34 1432508-73-0

CAS No.: 1432508-73-0

HDAC6-IN-34 (compound 21) is an orally active and selective HDAC6 inhibitor with an IC50 of 18 nM. HDAC6-IN-34 incr
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HDAC6-IN-34 (compound 21) is an orally active and selective HDAC6 inhibitor with an IC50 of 18 nM. HDAC6-IN-34 increases tubulin acetylation without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion from LPS-stimulated macrophages. HDAC6-IN-34 has a good anti-arthritis effect in rats.

Physicochemical Properties


Molecular Formula C18H18F3N3O3
Molecular Weight 381.35
CAS # 1432508-73-0
SMILES

C12C(=O)CC(C)(C)CC=1N(CC1C=CC(C(=O)NO)=CC=1)N=C2C(F)(F)F

Storage

Powder-20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Shipping Condition Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity


Targets HDAC6 18 nM (IC50); HDAC1 3.91 μM (IC50)
References

[1]. Development of a tetrahydroindazolone-based HDAC6 inhibitor with in-vivo anti-arthritic activity. Bioorg Med Chem. 2024 Feb 1;99:117587.


Solubility Data


Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.6223 mL 13.1113 mL 26.2226 mL
5 mM 0.5245 mL 2.6223 mL 5.2445 mL
10 mM 0.2622 mL 1.3111 mL 2.6223 mL
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.