Physicochemical Properties
Molecular Formula | C18H18F3N3O3 |
Molecular Weight | 381.35 |
CAS # | 1432508-73-0 |
SMILES | C12C(=O)CC(C)(C)CC=1N(CC1C=CC(C(=O)NO)=CC=1)N=C2C(F)(F)F |
Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
Targets | HDAC6 18 nM (IC50); HDAC1 3.91 μM (IC50) |
References |
[1]. Development of a tetrahydroindazolone-based HDAC6 inhibitor with in-vivo anti-arthritic activity. Bioorg Med Chem. 2024 Feb 1;99:117587. |
Solubility Data
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.6223 mL | 13.1113 mL | 26.2226 mL | |
5 mM | 0.5245 mL | 2.6223 mL | 5.2445 mL | |
10 mM | 0.2622 mL | 1.3111 mL | 2.6223 mL |