HCGRP-(8-37) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of CGRP receptors.

Physicochemical Properties

Molecular Formula	C139H230N44O38
Molecular Weight	3125.58549999999
Exact Mass	3123.74
CAS #	119911-68-1
Appearance	White to off-white solid powder
Density	1.46±0.1 g/cm3
LogP	1.115
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am J Physiol. 1989 Feb;256(2 Pt 1):E331-5.

Solubility Data

Solubility (In Vitro)	H2O : ≥ 20 mg/mL (~6.40 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 20 mg/mL (6.40 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.3199 mL	1.5997 mL	3.1994 mL
	5 mM	0.0640 mL	0.3199 mL	0.6399 mL
	10 mM	0.0320 mL	0.1600 mL	0.3199 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.