HB-3-20 induces degradation of cell surface integrin αVβ5. Transglutaminase 2 (TG2) is specific for HB-3-20 (kcat/KM=0.16 μM-1min-1).

Physicochemical Properties

Molecular Formula	C69H102N20O20
Molecular Weight	1531.67
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. J Am Chem Soc. 2023 Aug 30;145(34):18705-18710.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6529 mL	3.2644 mL	6.5288 mL
	5 mM	0.1306 mL	0.6529 mL	1.3058 mL
	10 mM	0.0653 mL	0.3264 mL	0.6529 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.