Guaiacol Carbonate, an expectorant, is transmitted to the center of the medulla oblongata through the gastric nerves, and then enters the respiratory tract through the periphery, where it has an expectorant effect through the gastric reflex.

Physicochemical Properties

Molecular Formula	C15H14O5
Molecular Weight	274.27
Exact Mass	274.084
CAS #	553-17-3
PubChem CID	11104
Appearance	White to off-white solid powder
Density	1.2±0.1 g/cm3
Boiling Point	392.6±27.0 °C at 760 mmHg
Melting Point	88°C
Flash Point	173.7±23.8 °C
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.552
LogP	2.41
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Heavy Atom Count	20
Complexity	279
Defined Atom Stereocenter Count	0
SMILES	COC1=CC=CC=C1OC(=O)OC2=CC=CC=C2OC
InChi Key	ORUJFMPWKPVXLZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C15H14O5/c1-17-11-7-3-5-9-13(11)19-15(16)20-14-10-6-4-8-12(14)18-2/h3-10H,1-2H3
Chemical Name	bis(2-methoxyphenyl) carbonate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Stevens ME, et al. On the Expectorant Action of Creosote and the Guaiacols. Can Med Assoc J. 1943;48(2):124-127.
Additional Infomation	Guaiacol carbonate is a member of methoxybenzenes.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (364.60 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (9.12 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.12 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.6460 mL	18.2302 mL	36.4604 mL
	5 mM	0.7292 mL	3.6460 mL	7.2921 mL
	10 mM	0.3646 mL	1.8230 mL	3.6460 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.