Ganciclovir mono-O-acetate is an analogue of Ganciclovir. Ganciclovir is a nucleoside analog and an orally bioactive antiviral molecule with activity against cytomegalovirus.

Physicochemical Properties

Molecular Formula	C11H15N5O5
Molecular Weight	297.27
Exact Mass	297.107
CAS #	88110-89-8
PubChem CID	135459820
Appearance	White to light yellow solid powder
Density	1.7±0.1 g/cm3
Boiling Point	607.8ºC at 760 mmHg
Melting Point	194-197ºC
Flash Point	321.4ºC
Index of Refraction	1.692
LogP	-1.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	21
Complexity	443
Defined Atom Stereocenter Count	0
SMILES	O=C1C2N=CN(C=2NC(N)=N1)COC(COC(C)=O)CO
InChi Key	YKLKCCHLLFMWQE-UHFFFAOYSA-N
InChi Code	InChI=1S/C11H15N5O5/c1-6(18)20-3-7(2-17)21-5-16-4-13-8-9(16)14-11(12)15-10(8)19/h4,7,17H,2-3,5H2,1H3,(H3,12,14,15,19)
Chemical Name	[2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Ganciclovir mono-o-acetate is an ester of ganciclovir that is mono-O-acetate.
References	[1]. Faulds D, et al. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39(4):597-638.

Solubility Data

Solubility (In Vitro)

DMSO : 50 mg/mL (168.20 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.41 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (8.41 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3639 mL	16.8197 mL	33.6395 mL
	5 mM	0.6728 mL	3.3639 mL	6.7279 mL
	10 mM	0.3364 mL	1.6820 mL	3.3639 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.