GW809897X is a dual inhibitor of Fluc and VEGFR with IC50 of 0.58 μM and 65 nM, respectively. GW809897X is a protein kinase inhibitor across ATP-dependent and -independent luciferases, with potential effects on Fluc reporter gene assays.

Physicochemical Properties

Molecular Formula	C26H24CL2N6O3S
Molecular Weight	571.48
CAS #	579515-94-9
SMILES	N(C1=C(Cl)C=CC=C1Cl)C(NC1=CC=C(N(C)C2C=CN=C(NC3=CC=CC(CS(C)(=O)=O)=C3)N=2)C=C1)=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. PLoS One. 2013;8(3):e57888.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7498 mL	8.7492 mL	17.4984 mL
	5 mM	0.3500 mL	1.7498 mL	3.4997 mL
	10 mM	0.1750 mL	0.8749 mL	1.7498 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.