GW701427A is a dual inhibitor of Fluc and VEGFR2 with IC50 of 0.12 μM and 603 nM, respectively. GW701427A acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, with potential effects on Fluc reporter gene assays.

Physicochemical Properties

Molecular Formula	C23H19N5O6
Molecular Weight	461.43
CAS #	433224-56-7
SMILES	N(C1=NC2=CC=C(C=C2N1)OC1C=CC(=CC=1)NC(=O)NC1C=CC=C(C=1)C(=O)O)C(=O)OC
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. PLoS One. 2013;8(3):e57888.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1672 mL	10.8359 mL	21.6718 mL
	5 mM	0.4334 mL	2.1672 mL	4.3344 mL
	10 mM	0.2167 mL	1.0836 mL	2.1672 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.