GSK1521498 free base is a potent and specific μ-opioid receptor blocker (antagonist). GSK1521498 free base is used to study diseases of compulsive eating, alcohol and reactive molecules.

Physicochemical Properties

Molecular Formula	C24H20F2N4
Molecular Weight	402.44
Exact Mass	326.134
CAS #	1007573-18-3
Related CAS #	GSK1521498 free base (hydrochloride);1007578-24-6;GSK1521498;1426543-84-1
PubChem CID	24737629
Appearance	White to off-white solid powder
LogP	3.397
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	30
Complexity	537
Defined Atom Stereocenter Count	0
InChi Key	WIEDUMBCZQRGSY-UHFFFAOYSA-N
InChi Code	InChI=1S/C24H20F2N4/c25-22-11-19(15-6-3-7-18(8-15)24-28-14-29-30-24)12-23(26)21(22)13-27-20-9-16-4-1-2-5-17(16)10-20/h1-8,11-12,14,20,27H,9-10,13H2,(H,28,29,30)
Chemical Name	N-[[2,6-difluoro-4-[3-(1H-1,2,4-triazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1H-inden-2-amine
Synonyms	GSK-1521498 GSK 1521498GSK1521498 GSK-1521498B
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. Neuropsychopharmacology. 2015 Dec;40(13):2981-92.
Additional Infomation	GSK1521498 has been used in trials studying the treatment of Obesity and Alcoholism.

Solubility Data

Solubility (In Vitro)

DMSO : ~11.36 mg/mL (~28.23 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1.67 mg/mL (4.15 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.4848 mL	12.4242 mL	24.8484 mL
	5 mM	0.4970 mL	2.4848 mL	4.9697 mL
	10 mM	0.2485 mL	1.2424 mL	2.4848 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.