GRK2i TFA is a GRK2 inhibitory peptide that specifically inhibits Gβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ binding domain and works as a cellular Gβγ antagonist.

Physicochemical Properties

Molecular Formula	C152H257F3N50O43S
Molecular Weight	3598.10
Related CAS #	GRK2i;148505-03-7
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci. 2014 Dec 31;15:132.

Solubility Data

Solubility (In Vitro)	H2O :~100 mg/mL (~27.79 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 50 mg/mL (13.90 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.2779 mL	1.3896 mL	2.7792 mL
	5 mM	0.0556 mL	0.2779 mL	0.5558 mL
	10 mM	0.0278 mL	0.1390 mL	0.2779 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.