GRGDSP (TFA) is an integrin inhibitor.

Physicochemical Properties

Molecular Formula	C24H38F3N9O12
Molecular Weight	701.61
Related CAS #	GRGDSP;91037-75-1
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Integrin[1].
ln Vitro	Transarterial GRGDSP infusion has been shown to be effective (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthesized linear RGD peptide, GRGDSP(Gly-Arg-Gly-Asp-Ser-Pro) can prevent tumor cells from adhering to blood vessel endothelial cells and restrict their ability to spread[1]. A soluble integrin-blocking RGD-based peptide called GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is employed. In integrin research, GRGDSP is frequently utilized in conjunction with other RGD peptides. In order to encourage endothelialization, GRGDSP can be applied to the surface of cardiovascular implants, such as vascular grafts[2].
References	[1]. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol. 2016 Jun 7;22(21):5042-9. [2]. Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J Biomed Mater Res A. 2007 Nov;83(2):423-33.

Solubility Data

Solubility (In Vitro)	H2O :~125 mg/mL (~178.16 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 50 mg/mL (71.26 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4253 mL	7.1265 mL	14.2529 mL
	5 mM	0.2851 mL	1.4253 mL	2.8506 mL
	10 mM	0.1425 mL	0.7126 mL	1.4253 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.