GNQWFI, an anti-Flt1 peptide, is a VEGFR1-specific antagonist. GNQWFI blocks the interaction of VEGFR1 with multiple VEGFR1 ligands, such as VEGFA, VEGFB, and placental growth factor (PIGF), and inhibits VEGF-induced endothelial cell migration and tubule formation. GNQWFI has the potential to be used in the study of cancer, asthma, and other eye diseases.

Physicochemical Properties

Molecular Formula	C37H49N9O9
Molecular Weight	763.84
CAS #	853995-60-5
SMILES	C(O)(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CN
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	VEGFR1 Flt-1
References	[1]. Synthesis, characterization, and preliminary assessment of anti-Flt1 peptide-hyaluronate conjugate for the treatment of corneal neovascularization. Biomaterials. 2009 Oct;30(30):6026-34.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3092 mL	6.5459 mL	13.0917 mL
	5 mM	0.2618 mL	1.3092 mL	2.6183 mL
	10 mM	0.1309 mL	0.6546 mL	1.3092 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.