GK187 is a potent and specific inhibitor of Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) with an XI(50) value of 0.0001. GK187 may be utilized in study/research of a variety of neurological diseases.

Physicochemical Properties

Molecular Formula	C14H15F5O2
Molecular Weight	310.264
Exact Mass	310.099
CAS #	1071001-50-7
PubChem CID	25060072
Appearance	Colorless to light yellow liquid
Density	1.2±0.1 g/cm3
Boiling Point	330.3±42.0 °C at 760 mmHg
Flash Point	148.5±22.8 °C
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.438
LogP	5.32
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	21
Complexity	333
Defined Atom Stereocenter Count	0
SMILES	FC(C(F)(F)F)(C(CCCCC1C=CC(=CC=1)OC)=O)F
InChi Key	CICDFDPOGZQTQB-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H15F5O2/c1-21-11-8-6-10(7-9-11)4-2-3-5-12(20)13(15,16)14(17,18)19/h6-9H,2-5H2,1H3
Chemical Name	1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)heptan-3-one
Synonyms	GK 187; GK-187; GK187
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15;21(18):5823-9.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~322.31 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.06 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.06 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (8.06 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2231 mL	16.1155 mL	32.2310 mL
	5 mM	0.6446 mL	3.2231 mL	6.4462 mL
	10 mM	0.3223 mL	1.6116 mL	3.2231 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.