G907 is a selective, bactericidal ( bacteria killing) antagonist of the ATP-binding cassette (ABC) transporter MsbA. G907 inhibits Escherichia coli MsbA with IC50 of 18 nM. G907 traps MsbA in an inward-facing lipopolysaccharide-binding conformation by wedged into a structurally conserved transmembrane pocket.

Physicochemical Properties

Molecular Formula	C26H24CLNO3
Molecular Weight	433.926666259766
Exact Mass	433.144
CAS #	2244035-16-1
PubChem CID	139035046
Appearance	Typically exists as solid at room temperature
LogP	6.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Heavy Atom Count	31
Complexity	676
Defined Atom Stereocenter Count	0
SMILES	CC(C1=C(C=CC=C1Cl)C2CC2)OC3=CC4=C(C(=CN=C4C=C3)/C=C/C(=O)O)C5CC5
InChi Key	HOMQCLNBKVHZGD-FMIVXFBMSA-N
InChi Code	InChI=1S/C26H24ClNO3/c1-15(25-20(16-5-6-16)3-2-4-22(25)27)31-19-10-11-23-21(13-19)26(17-7-8-17)18(14-28-23)9-12-24(29)30/h2-4,9-17H,5-8H2,1H3,(H,29,30)/b12-9+
Chemical Name	(E)-3-[6-[1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	G907 (0.1 nM-100 μM) completely suppresses Escherichia coli MsbA activity, with an IC50 value of 18 nM[1]. G907 has MsbA-blocking allosteric inhibition action [1]. WT pontics biotin-PE transport activity [2].
References	[1]. Ho H, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201. [2]. Guo D, et al. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent. Commun Biol. 2021 Dec 9;4(1):1379.

Solubility Data

Solubility (In Vitro)

DMSO : ~83.33 mg/mL (~192.04 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (4.79 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3045 mL	11.5226 mL	23.0452 mL
	5 mM	0.4609 mL	2.3045 mL	4.6090 mL
	10 mM	0.2305 mL	1.1523 mL	2.3045 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.