G3-C12 (TFA) is a galectin-3 binding peptide with Kd of 88 nM and has anti-tumor activity.

Physicochemical Properties

Molecular Formula	C74H115N23O23S2.C2HF3O2
Molecular Weight	1873.00
Related CAS #	G3-C12;848301-94-0
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Galectin-3
ln Vitro	G3-C12(TFA) is a peptide that binds to galectin-3 with a high affinity (Kd) of 88 nM; it has no affinity for other lectins or members of the galectin family. When compared to the galactose containing copolymer, G3-C12(TFA) bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) exhibits improved targetability to galectin-3 and can effectively and selectively target colorectal cancer (CRC) tumor cells that overexpress galectin-3[1].
References	[1]. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.

Solubility Data

Solubility (In Vitro)	H2O :≥ 50 mg/mL (~26.70 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 12.5 mg/mL (6.67 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.5339 mL	2.6695 mL	5.3390 mL
	5 mM	0.1068 mL	0.5339 mL	1.0678 mL
	10 mM	0.0534 mL	0.2670 mL	0.5339 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.