Furprofen is a nonsteroidal anti~inflammatory agent (NSAID). Furprofen works by inhibiting prostaglandin (PGE) synthesis. Furprofen taken by mouth can reduce pain.

Physicochemical Properties

Molecular Formula	C14H12O4
Molecular Weight	244.24268
Exact Mass	244.074
CAS #	66318-17-0
PubChem CID	162201
Appearance	Light yellow to yellow ointment
Density	1.252g/cm3
Boiling Point	425.5ºC at 760 mmHg
Flash Point	211.1ºC
Index of Refraction	1.571
LogP	2.698
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Heavy Atom Count	18
Complexity	318
Defined Atom Stereocenter Count	0
SMILES	CC(C1=CC=C(C=C1)C(=O)C2=CC=CO2)C(=O)O
InChi Key	ITJUVDBADHDNPU-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H12O4/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
Chemical Name	2-[4-(furan-2-carbonyl)phenyl]propanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A high performance liquid chromatographic procedure for the simultaneous determination of norfloxacin and furprofen in rat plasma. Biomed Chromatogr. 1993 May-Jun;7(3):126-8. [2]. Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine. J Chromatogr A. 2014 Nov 7;1367:1-8.

Solubility Data

Solubility (In Vitro)

Ethanol : ~100 mg/mL (~409.43 mM) DMSO : ~62.5 mg/mL (~255.90 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.17 mg/mL (8.88 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.17 mg/mL (8.88 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.0943 mL	20.4717 mL	40.9433 mL
	5 mM	0.8189 mL	4.0943 mL	8.1887 mL
	10 mM	0.4094 mL	2.0472 mL	4.0943 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.