Fmoc-Trp(Me)-OH is a compound synthesized from (Fmoc-ONSu and 1-Methyl-Ltrypthophan, which can be used for protein or peptide synthesis.

Physicochemical Properties

Molecular Formula	C27H24N2O4
Molecular Weight	440.49
Exact Mass	440.173
CAS #	1334509-86-2
PubChem CID	53832785
Appearance	White to off-white solid powder
Density	1.3±0.1 g/cm3
Boiling Point	699.7±55.0 °C at 760 mmHg
Flash Point	376.9±31.5 °C
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.663
LogP	5.73
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Heavy Atom Count	33
Complexity	692
Defined Atom Stereocenter Count	1
SMILES	CN1C=C(C2=CC=CC=C21)C[C@H](NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)C(O)=O
InChi Key	GDPXIUSEXJJUGT-DEOSSOPVSA-N
InChi Code	InChI=1S/C27H24N2O4/c1-29-15-17(18-8-6-7-13-25(18)29)14-24(26(30)31)28-27(32)33-16-23-21-11-4-2-9-19(21)20-10-3-5-12-22(20)23/h2-13,15,23-24H,14,16H2,1H3,(H,28,32)(H,30,31)/t24-/m0/s1
Chemical Name	(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-methylindol-3-yl)propanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Self-Assembled Surfactant Cyclic Peptide Nanostructures as Stabilizing Agents. Soft Matter. 2013 Oct 21;9(39).

Solubility Data

Solubility (In Vitro)

DMSO: 62.5 mg/mL (141.89 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.08 mg/mL (4.72 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2702 mL	11.3510 mL	22.7020 mL
	5 mM	0.4540 mL	2.2702 mL	4.5404 mL
	10 mM	0.2270 mL	1.1351 mL	2.2702 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.