Fludarabine-Cl has an inhibitory activity against RNA adenosine deaminase 1 (ADAR1) and may be utilized to prevent and/or study cancer or tumor-related diseases.

Physicochemical Properties

Molecular Formula	C10H11CLFN5O3
Molecular Weight	303.677443742752
Exact Mass	303.053
CAS #	2734853-80-4
PubChem CID	162354766
Appearance	Typically exists as White to off-white solids at room temperature
LogP	0.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Heavy Atom Count	20
Complexity	370
Defined Atom Stereocenter Count	4
SMILES	C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CCl)O)O)F)N
InChi Key	HSCKXTNMVCTWGY-UUOKFMHZSA-N
InChi Code	InChI=1S/C10H11ClFN5O3/c11-1-3-5(18)6(19)9(20-3)17-2-14-4-7(13)15-10(12)16-8(4)17/h2-3,5-6,9,18-19H,1H2,(H2,13,15,16)/t3-,5-,6-,9-/m1/s1
Chemical Name	(2R,3R,4S,5S)-2-(6-amino-2-fluoropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol
Synonyms	Fludarabine-Cl; 2734853-80-4; Fludarabine-Cl?; SCHEMBL24981041; MS-24385;
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	ADAR1/RNA adenosine deaminase 1
ln Vitro	Fludarabine-Cl has potent inhibitory effects on RNA adenosine deaminase 1 (ADAR1), and can be used to prevent and/or treat cancer or tumor related diseases caused by abnormal activity of this enzyme, especially prostate cancer, leukemia, breast cancer, multiple myeloma, lung cancer, stomach cancer, ovarian cancer, colon cancer, liver cancer, pancreatic cancer.
References	Polysubstituted purine compound and preparation method and application thereof. CN113549076A.

Solubility Data

Solubility (In Vitro)	H2O : ~5 mg/mL (~16.46 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 2 mg/mL (6.59 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2929 mL	16.4647 mL	32.9294 mL
	5 mM	0.6586 mL	3.2929 mL	6.5859 mL
	10 mM	0.3293 mL	1.6465 mL	3.2929 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.