Flonoltinib maleate is an orally active dual JAK2/FLT3 inhibitor with IC50 of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib maleate has anticancer activity.

Physicochemical Properties

Molecular Formula	C25H36FN7O5S
Molecular Weight	565.66
CAS #	2568842-57-7
Related CAS #	Flonoltinib;2387765-27-5;Flonoltinib TFA;2928093-29-0;Flonoltinib monomaleate
SMILES	S(=O)(=O)(O)O.FC1C=C(C=CC=1N1CCC(CC1)N(C)CCO)NC1N=CC(C)=C(C2C=NN(C=2)C(C)C)N=1
Synonyms	JAK2/FLT3-IN-1 sulfate
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Flonoltinib maleate (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner[1]. Flonoltinib maleate (5-100 nM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells[1]. Flonoltinib maleate (5-100 nM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells[1].
ln Vivo	Flonoltinib maleate (30 and 60 mg/kg/day; po; for 14 days) exhibits significant antitumor effects[1].
References	[1]. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7678 mL	8.8392 mL	17.6785 mL
	5 mM	0.3536 mL	1.7678 mL	3.5357 mL
	10 mM	0.1768 mL	0.8839 mL	1.7678 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.