Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor (antagonist) with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

Physicochemical Properties

Molecular Formula	C16H20O9
Molecular Weight	356.32
Exact Mass	356.111
CAS #	7196-71-6
PubChem CID	13962928
Appearance	White to off-white solid powder
LogP	-0.3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Heavy Atom Count	25
Complexity	469
Defined Atom Stereocenter Count	5
SMILES	COC1=C(C=CC(=C1)/C=C/C(=O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O
InChi Key	JWRQVQWBNRGGPK-PMQCXRHVSA-N
InChi Code	InChI=1S/C16H20O9/c1-23-10-6-8(2-4-9(10)18)3-5-12(19)25-16-15(22)14(21)13(20)11(7-17)24-16/h2-6,11,13-18,20-22H,7H2,1H3/b5-3+/t11-,13-,14+,15-,16+/m1/s1
Chemical Name	[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Metabolism of ferulic acid in rats. J Asian Nat Prod Res. 2005;7(1):49-58. [2]. Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci. 2015 Oct 12;16(10):24011-31.

Additional Infomation

1-O-feruloyl-beta-D-glucose is a beta-D-glucoside resulting from the formal condensation of the carboxy group of ferulic acid with the anomeric hydroxy group of beta-D-glucose. It has a role as an antioxidant and a plant metabolite. It is a beta-D-glucoside, a cinnamate ester, a member of phenols and an aromatic ether. It is functionally related to a ferulic acid. 1-O-feruloyl-beta-D-glucose has been reported in Camellia sinensis, Ligustrum obtusifolium, and other organisms with data available.

Solubility Data

Solubility (In Vitro)	H2O: 50 mg/mL (140.32 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 25 mg/mL (70.16 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8065 mL	14.0323 mL	28.0647 mL
	5 mM	0.5613 mL	2.8065 mL	5.6129 mL
	10 mM	0.2806 mL	1.4032 mL	2.8065 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.