Ferroptosis-IN-17 (Compound 18) is a ferroptosis inhibitor with an EC50 value of 0.57 μM. Ferroptosis-IN-17 reduces intracellular ferrous ion accumulation, lipid peroxidation, and effectively restores glutathione (GSH) and glutathione peroxidase 4 (GPX4) levels. Ferroptosis-IN-17 exhibits good solubility and significant metabolic stability in rat plasma. Ferroptosis-IN-17 is expected to be used in the research of tumor suppression, neurodegenerative diseases, and cardiovascular diseases.

Physicochemical Properties

Molecular Formula	C21H26N4O5S
Molecular Weight	446.52
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Design, Synthesis, and Biological Evaluation of New Improved Ferrostatin-1 Derived Ferroptosis Inhibitors. Chem Biodivers. 2024 Oct 4:e202402141.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2395 mL	11.1977 mL	22.3954 mL
	5 mM	0.4479 mL	2.2395 mL	4.4791 mL
	10 mM	0.2240 mL	1.1198 mL	2.2395 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.