Fenipentol (1-Phenyl-1-pentanol) is a synthetic analogue of the component turmeric used as a flavoring and dye. Fenipentol is also an orally bioactive choleretic that plays an important role in the release of bicarbonate and protein secretin, gastrin and pancreatic secretion.

Physicochemical Properties

Molecular Formula	C11H16O
Molecular Weight	164.24
Exact Mass	164.12
CAS #	583-03-9
PubChem CID	3338
Appearance	Colorless to light yellow liquid
Density	0,96 g/cm3
Boiling Point	137°C 2mm
Flash Point	137°C/2mm
Index of Refraction	1.5080
LogP	2.91
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	4
Heavy Atom Count	12
Complexity	106
Defined Atom Stereocenter Count	0
SMILES	CCCCC(C1=CC=CC=C1)O
InChi Key	OVGORFFCBUIFIA-UHFFFAOYSA-N
InChi Code	InChI=1S/C11H16O/c1-2-3-9-11(12)10-7-5-4-6-8-10/h4-8,11-12H,2-3,9H2,1H3
Chemical Name	1-phenylpentan-1-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	The secretory volume of pancreatic juice and protein output in rats are increased by fenipentol (PHP) administered orally or intraduodenally at doses ranging from 50-200 mg/kg[2]. In rats, fenipentol (50–200 mg/kg for intraperitoneal and 5–10 mg/kg for intravenous) significantly enhances biliary secretion[2]. In dogs, fenipentol (25–200 mg/kg administered intraduodenally) promotes pancreatic secretion[2].
References	[1]. Therapeutic properties of dihydroxy-dibutylether on sub-acute liver damage induced by several hepatotoxic agents in rats. Int J Tissue React. 1982; 4(4): 309-18. [2]. [Effect of 1-phenyl-1-hydroxy-n-pentane on pancreatic secretion in the rat and the dog]. Nihon Yakurigaku Zasshi. 1971 Nov; 67(6): 637-47. [3]. Biocatalytic and electrochemical reduction of selected phenyl alkanones with antibacterial activity of the corresponding phenyl alkanols. Ijabpt Com, 2011.
Additional Infomation	Fenipentol is a member of benzenes. Fenipentol has been reported in Ligusticum striatum, Vincetoxicum glaucescens, and Ligusticum chuanxiong with data available.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (608.87 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.0887 mL	30.4433 mL	60.8865 mL
	5 mM	1.2177 mL	6.0887 mL	12.1773 mL
	10 mM	0.6089 mL	3.0443 mL	6.0887 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.