FPT is a 2-aminotetralin that is a potent partial agonist of 5-HT1AR and a full agonist of 5-HT1BR and 5-HT1DR with EC50 of 39.3 nM, 1.2 nM, and 0.5 nM, respectively. FPT is a weak agonist of 5-HT7R. FPT exhibits anti-epileptic effects in Fmr1 knockout mice and has anxiolytic and prosocial effects in mouse models.

Physicochemical Properties

Molecular Formula	C18H20FN
Molecular Weight	269.36
CAS #	2048491-06-9
Appearance	Colorless to light yellow liquid（Density：1.119±0.10 g/cm3）
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	5-HT1A Receptor 39.3 nM (IC50) 5-HT1B Receptor 1.2 nM (IC50) 5-HT1D Receptor 0.5 nM (IC50) 5-HT1A Receptor 4.3 nM (Ki) 5-HT1B Receptor 2.3 nM (Ki) 5-HT1D Receptor 1.2 nM (Ki) 5-HT1F Receptor >10,000 nM (Ki) 5-HT7 Receptor
References	[1]. Tanishka S Saraf, et al. FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice. ACS Chem Neurosci. 2022 Dec 21;13(24):3629-3640.

Solubility Data

Solubility (In Vitro)

DMSO : ~66.67 mg/mL (~247.51 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (18.56 mM) (saturation unknown) in 10% DMSO +90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution。 For example, if 1 mL of working solution is to be prepared, You can add 100 μL of the 50.0 mg/mL clear DMSO stock solution to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.7125 mL	18.5625 mL	37.1250 mL
	5 mM	0.7425 mL	3.7125 mL	7.4250 mL
	10 mM	0.3713 mL	1.8563 mL	3.7125 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.