FLT3 Ligand-Linker Conjugate 1 contains FLT3 ligand and PROTAC linker, which can recruit E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize PROTAC RSS0680. PROTAC RSS0680 is a bifunctional compound that targets protein degradation kinases.

Physicochemical Properties

Molecular Formula	C29H34N6O4S2
Molecular Weight	594.75
CAS #	2769753-49-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742P. 2022-05-05.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6814 mL	8.4069 mL	16.8138 mL
	5 mM	0.3363 mL	1.6814 mL	3.3628 mL
	10 mM	0.1681 mL	0.8407 mL	1.6814 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.