FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 (FEN1) inhibitor (CN106692155A, SC13).

Physicochemical Properties

Molecular Formula	C24H23N3O3S
Molecular Weight	433.52272439003
Exact Mass	433.146
CAS #	2098776-03-3
PubChem CID	162623411
Appearance	Off-white to light yellow solid powder
LogP	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Heavy Atom Count	31
Complexity	667
Defined Atom Stereocenter Count	0
SMILES	S1C=CC2=C1C(N(CCC)C(N2CC1C=CC=C(C=1)NC(CC1C=CC=CC=1)=O)=O)=O
InChi Key	USTMMKOHIRMBIV-UHFFFAOYSA-N
InChi Code	InChI=1S/C24H23N3O3S/c1-2-12-26-23(29)22-20(11-13-31-22)27(24(26)30)16-18-9-6-10-19(14-18)25-21(28)15-17-7-4-3-5-8-17/h3-11,13-14H,2,12,15-16H2,1H3,(H,25,28)
Chemical Name	N-[3-[(2,4-dioxo-3-propylthieno[3,2-d]pyrimidin-1-yl)methyl]phenyl]-2-phenylacetamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Application of small-molecular inhibitor SC13 targeting to FEN1 and derivative of small-molecular inhibitor SC13 in preparing tumor treatment medicine. CN106692155A.

Solubility Data

Solubility (In Vitro)

DMSO : ~62.5 mg/mL (~144.17 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (4.80 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3067 mL	11.5335 mL	23.0670 mL
	5 mM	0.4613 mL	2.3067 mL	4.6134 mL
	10 mM	0.2307 mL	1.1533 mL	2.3067 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.