FBnG is a component of a nonribosomal peptide synthetase/polyketide synthetase (NRPS/PKS) involved in the biosynthesis of fabrubactin (FBN). FBnG can be used to synthesize AUTAC4 as part of FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2.

Physicochemical Properties

Molecular Formula	C17H17FN6O4S
Molecular Weight	420.42
CAS #	2241669-86-1
Appearance	White to yellow solid powder
SMILES	S(CC(C(=O)O)NC(C)=O)C1=NC2C(NC(N)=NC=2N1CC1C=CC(=CC=1)F)=O
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Vinnik V, et al., Structural and Biosynthetic Analysis of the Fabrubactins, Unusual Siderophores from Agrobacterium fabrum Strain C58. ACS Chem Biol. 2021 Jan 15;16(1):125-135.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~237.86 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (4.95 mM) (saturation unknown) in 10% DMSO +90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution。 For example, if 1 mL of working solution is to be prepared, You can add 100 μL of the 20.8 mg/mL clear DMSO stock solution to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3786 mL	11.8929 mL	23.7857 mL
	5 mM	0.4757 mL	2.3786 mL	4.7571 mL
	10 mM	0.2379 mL	1.1893 mL	2.3786 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.