Eutypenes I (Compound 9) inhibits the secretion of VEGF-A, inhibits the activation of VEGFR and its downstream Erk/Akt signaling pathway. Eutypenes I inhibits the migration of HMEC-1 cells and exhibits anti-angiogenic activity in the Sprague-Dawley rat model.

Physicochemical Properties

Molecular Formula	C15H24O3
Molecular Weight	252.35
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of marine ent-eudesmane sesquiterpenoids as angiogenic inhibitors via suppressing VEGF-A/VEGFR2 signaling pathway. Bioorg Chem. 2025 Jan;154:108055.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.9628 mL	19.8138 mL	39.6275 mL
	5 mM	0.7926 mL	3.9628 mL	7.9255 mL
	10 mM	0.3963 mL	1.9814 mL	3.9628 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.