Euphorbia factor L2 is an erythritane diterpene (Euphorbia lathyris L.) extracted from Euphorbia lathyris L., which has anti-cancer activity. Euphorbia factor L2 displays strong cytotoxic effect and causes apoptosis through the mitochondrial pathway.

Physicochemical Properties

Molecular Formula	C38H42O9
Molecular Weight	642.73
Exact Mass	642.282
CAS #	218916-51-9
PubChem CID	101071473
Appearance	White to off-white solid powder
Density	1.2±0.1 g/cm3
Boiling Point	697.6±55.0 °C at 760 mmHg
Flash Point	284.6±31.5 °C
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.582
LogP	8.36
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	10
Heavy Atom Count	47
Complexity	1300
Defined Atom Stereocenter Count	8
SMILES	C[C@H]1C[C@]2([C@H]([C@H]1OC(=O)C3=CC=CC=C3)[C@H](C(=C)[C@@H](C[C@H]4[C@H](C4(C)C)/C=C(\C2=O)/C)OC(=O)C5=CC=CC=C5)OC(=O)C)OC(=O)C
InChi Key	AFRGWGGHJYMSDU-NKGNXCQNSA-N
InChi Code	InChI=1S/C38H42O9/c1-21-18-28-29(37(28,6)7)19-30(45-35(42)26-14-10-8-11-15-26)23(3)33(44-24(4)39)31-32(46-36(43)27-16-12-9-13-17-27)22(2)20-38(31,34(21)41)47-25(5)40/h8-18,22,28-33H,3,19-20H2,1-2,4-7H3/b21-18-/t22-,28+,29-,30+,31+,32-,33-,38+/m0/s1
Chemical Name	[(1R,3Z,5R,7S,9R,11R,12R,13S,14S)-1,11-diacetyloxy-13-benzoyloxy-3,6,6,14-tetramethyl-10-methylidene-2-oxo-9-tricyclo[10.3.0.05,7]pentadec-3-enyl] benzoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway. Acta Pharm Sin B. 2017 Jan;7(1):59-64.
Additional Infomation	[(1R,3Z,5R,7S,9R,11R,12R,13S,14S)-1,11-diacetyloxy-13-benzoyloxy-3,6,6,14-tetramethyl-10-methylidene-2-oxo-9-tricyclo[10.3.0.05,7]pentadec-3-enyl] benzoate has been reported in Euphorbia lathyris with data available.

Solubility Data

Solubility (In Vitro)

DMSO : 83.33 mg/mL (129.65 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 6.25 mg/mL (9.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.5559 mL	7.7793 mL	15.5586 mL
	5 mM	0.3112 mL	1.5559 mL	3.1117 mL
	10 mM	0.1556 mL	0.7779 mL	1.5559 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.