Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that reduces NF-κB p65 phosphorylation and has anti-inflammatory activity. Euphjatrophane M inhibits the production of nitric oxide and also suppresses the mRNA expression of IL-6, IL-1β, and TNFα in RAW 264.7 macrophages induced by lipopolysaccharide (LPS).

Physicochemical Properties

Molecular Formula	C20H28O4
Molecular Weight	332.43
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	FOXO1
References	[1]. Highly oxygenated ent-abietane diterpenoid lactones from Euphorbia peplus and their anti-inflammatory activity. Bioorg Chem. 2024 Nov 22:154:107989.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.0082 mL	15.0408 mL	30.0815 mL
	5 mM	0.6016 mL	3.0082 mL	6.0163 mL
	10 mM	0.3008 mL	1.5041 mL	3.0082 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.