EGFR WT/T790M-IN-2 (Compound 7c) is an EGFR T790M/WT inhibitor with IC50 values of 0.08 and 0.13 μM, respectively. EGFR WT/T790M-IN-2 induces apoptosis by arresting the G0-G1 phase. EGFR WT/T790M-IN-2 has antitumor activity.

Physicochemical Properties

Molecular Formula	C19H13CLFN5S
Molecular Weight	397.86
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	EGFRT790M 0.08 μM (IC50); EGFRWT 0.13 μM (IC50)
References	[1]. Novel Pyrimidine-5-Carbonitriles as potential apoptotic and antiproliferative agents by dual inhibition of EGFRWT/T790M and PI3k enzymes; Design, Synthesis, biological Evaluation, and docking studies. Bioorg Chem. 2024 Feb 9;145:107185.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5134 mL	12.5672 mL	25.1345 mL
	5 mM	0.5027 mL	2.5134 mL	5.0269 mL
	10 mM	0.2513 mL	1.2567 mL	2.5134 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.