EGFR/VEGFR2-IN-2 (compound 4b) is a dual inhibitor of VEGFR-2 and EGFR.

Physicochemical Properties

Molecular Formula	C24H15FO3
Molecular Weight	370.37
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Synthesis and in vitro exploration of the 8-carbo substituted 5-methoxyflavones as anti-breast and anti-lung cancer agents targeting protein kinases (VEGFR-2 & EGFR). Bioorg Chem. 2024 Dec;153:107875.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.7000 mL	13.5000 mL	27.0000 mL
	5 mM	0.5400 mL	2.7000 mL	5.4000 mL
	10 mM	0.2700 mL	1.3500 mL	2.7000 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.