EGFR-TK-IN-2 (compound 10b) is an EGFR-TK inhibitor with IC50 of 0.16 μM. EGFR-TK-IN-2 inhibits cell proliferation.

Physicochemical Properties

Molecular Formula	C22H19N3O3
Molecular Weight	373.40
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	EGFR-TK-IN-2 (compound 10b) inhibits cell proliferation with IC50 values of 9.94 μM, 6.32 μM and 8.11 μM for HCT116, HePG-2 and MCF7, respectively[1].
References	[1]. M. New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study. Sci Rep. 2024;14(1):5474. Published 2024 Mar 5.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6781 mL	13.3905 mL	26.7809 mL
	5 mM	0.5356 mL	2.6781 mL	5.3562 mL
	10 mM	0.2678 mL	1.3390 mL	2.6781 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.