EGFR T790M/L858R-IN-5 (example 52) is a potent inhibitor of EGFR T790M/L858R, with an inhibition rate of 92.9% at 0.05 μM.

Physicochemical Properties

Molecular Formula	C28H31N9O
Molecular Weight	509.61
CAS #	3032760-70-3
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. dvenchen Pharmaceuticals, LLC. Preparation of pyrimidine compound as kinase inhibitors with biological activities on EGFR mutants. World Intellectual Property Organization, WO2024064091 A1 2024-03-28https://patents.google.com/patent/WO2024064091A1/en?oq=WO2024064091A1.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9623 mL	9.8114 mL	19.6228 mL
	5 mM	0.3925 mL	1.9623 mL	3.9246 mL
	10 mM	0.1962 mL	0.9811 mL	1.9623 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.