EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with IC50 of 0.15 μM. EGFR-IN-143 induces apoptosis by arresting the cell cycle at the G2/M phase. EGFR-IN-143 has anti-tumor activity.

Physicochemical Properties

Molecular Formula	C20H21CLN6O3
Molecular Weight	428.87
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Exploring 1,2,3-triazole-Schiff's base hybrids as innovative EGFR inhibitors for the treatment of breast cancer: In vitro and in silico study. Bioorg Chem. 2025 Jan 3;155:108106.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3317 mL	11.6585 mL	23.3171 mL
	5 mM	0.4663 mL	2.3317 mL	4.6634 mL
	10 mM	0.2332 mL	1.1659 mL	2.3317 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.