EGFR-IN-142 (compound 9a) is an EGFR inhibitor with an IC50 value of 0.08 μM. EGFR-IN-142 has antiproliferative effects on MCF-7 (IC50 3.31 µM) and WI-38 (IC50 = 43.99 µM).

Physicochemical Properties

Molecular Formula	C24H20N8O2S7
Molecular Weight	676.92
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Design, Synthesis, Biological Evaluation and Molecular Docking Study of New 1,3,4-Thiadiazole-Based Compounds as EGFR Inhibitors. Drug Dev Res. 2025 Feb;86(1):e70035.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4773 mL	7.3864 mL	14.7728 mL
	5 mM	0.2955 mL	1.4773 mL	2.9546 mL
	10 mM	0.1477 mL	0.7386 mL	1.4773 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.