EGFR-IN-141 (Compound 8I) is an inhibitor of EGFR with IC50 of 2.67 nM. EGFR-IN-141 exhibits cytotoxicity in cancer cells A549 with IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization, and exhibits potential antitumor activity.

Physicochemical Properties

Molecular Formula	C20H15FN8O2S2
Molecular Weight	482.51
CAS #	3054263-27-0
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	EGFR 2.67 nM (IC50)
References	[1]. Pharmacophore‐Based Modeling, Synthesis, and Biological Evaluation of Novel Quinazoline/Quinoline Derivatives: Discovery of EGFR Inhibitors with Low Nanomolar ActivityJ. Advanced Theory and Simulations, 2024: 2400811.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0725 mL	10.3625 mL	20.7250 mL
	5 mM	0.4145 mL	2.0725 mL	4.1450 mL
	10 mM	0.2072 mL	1.0362 mL	2.0725 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.