EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of <0.3 nM, 0.52 nM, 0.5 nM, 0.69 nM and 0.92 nM for EGFR (d746-750/T790M/C779S), EGFR (L858R/T790M/C797S), EGFR (d746-750/C797S), EGFR (L858R/C797S) and EGFR (wild type), respectively.

Physicochemical Properties

Molecular Formula	C30H26N8O
Molecular Weight	514.58
CAS #	2472802-77-8
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	EGFR (L858R/T790M/C797S) 0.52 nM (IC50); EGFR (d746-750/T790M/C779S) <0.3 nM (IC50); EGFR (d746-750/C797S) 0.5 nM (IC50); EGFR (WT) 0.92 nM (IC50)
References	[1]. 7H-pyrrolo 2,3-d pyrimidine-4-amine derivative.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9433 mL	9.7167 mL	19.4333 mL
	5 mM	0.3887 mL	1.9433 mL	3.8867 mL
	10 mM	0.1943 mL	0.9717 mL	1.9433 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.